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Overview of Residual Limb Pain

Residual limb pain (RLP) is pain that develops at the site of an amputation. It’s different from phantom pain, which is felt in the amputated part of the limb that is no longer part of the body. The pain associated with RLP, which is also commonly referred to as “stump pain,” can feel like cramping, aching, burning, or sensations of hot and cold.

There are numerous potential causes of residual limb pain. The most common cause, according to Amputee Coalition, is an underlying condition that is either related to the surgical procedure or that was present prior to the amputation. From the surgery, skin problems, infections can develop. From diabetes or other circulatory problems, neuropathy can arise and cause residual limb pain. Trauma caused from the surgery, such as a decrease in blood supply or a loss of tissue covering and protecting the end of the bone can also cause residual limb pain. In addition, the formation of neuroma, bone spurs, or the entrapment of nerves in scar tissue are not uncommon and can be causes.

Following a lower limb amputation, because of altered gait pattern, decreased weight load, disuse atrophy and lack of muscular action, it’s not uncommon for those with residual limb pain to also develop osteoporosis, or a loss in bone density (Yazicioglu, et al., 2008).

While pain medications are commonly used to help manage discomfort, treatments for residual limb pain also focus on managing the underlying cause of the pain. For pre-existing conditions like diabetes, treatment focus is on managing the condition through medications and lifestyle changes. When a loss of tissue or the development of bone spurs is the cause, additional padding and prosthetic adjustments may help, but in some causes surgery may be necessary to revise the residual limb or remove the extra bone. To treat residual limb pain caused by neuromas, non-steroidal anti–inflammatory, antidepressant and anticonvulsant medications, as well as ultrasound, massage, vibration, percussion, acupuncture and transcutaneous electrical nerve stimulation are traditionally effective for reducing pain.

Findings: Effects of Cannabis on Reflex sympathetic dystrophy

Studies have shown that cannabis and its cannabinoids have analgesic, anticonvulsant and antidepressant effects, which means it could potentially help manage residual limb pain. This is significant, as one study found that 67.7% of amputees experienced residual limb pain and a quarter of those reported that the pain they experienced was “extremely bothersome” (Ephraim, et al., 2005).

Tetrahydrocannabinol (THC) and cannabidiol (CBD), two major cannabinoids found in cannabis, have been shown to effectively reduce pain caused by cancer, neuropathy, spasticity, headache, migraines, and other acute pain and chronic pain conditions (Jensen, Chen, Furnish & Wallace, 2015) (Baron, 2015). THC and CBD are agonists of the two main cannabinoid receptors (CB1 and CB2) of the endocannabinoid system within the body. These receptors regulate the release of neurotransmitter and central nervous system immune cells to manage pain levels (Woodhams, Sagar, Burston & Chapman, 2015). As a result, the cannabinoids have demonstrated the ability to significantly lower neuropathic and nociceptive pain, and has even shown it can help manage pain that has proven refractory to other treatments (Boychuck, Goddard, Mauro & Orellana, 2015) (Wallace, et al., 2015) (Lynch & Campbell, 2011).

Cannabis can also help those whose residual limb pain is caused from diabetes. Cannabis use has been found to have an inverse association with diabetes (Alshaarawy & Anthony, 2015). In addition, in animal trials, CBD was shown to significantly reduce both pro-inflammatory cytokines in the bloodstream and the incidence of diabetes in non-obese mice (Weiss, et al., 2006). Later, those same researchers found that CBD was effective at curtailing the manifestations of the disease. Only 30% of the CBD-treated mice in a latent diabetes stage or with initial symptoms of diabetes ended up developing diabetes (Weiss, et al., 2008).

Cannabis also can reduce the risk of those with residual limb pain from developing osteoporosis. THC’s activation of the CB2 receptor has been shown to stimulate bone formation and inhibit bone breakdown (Bab, Zimmer & Melamed, 2009). Even low concentrates of cannabinoids have been shown to be effective at activating human osteoclasts, thus boosting bone density and offering therapeutic benefits to bone disease (Whyte, et al., 2012).



Alshaarawy, O., and Anthony, J.C. (2015, July). Cannabis Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples. Epidemiology, 26(4), 597-600. Retrieved from

Bab, I., Zimmer, A. and Melamed, E. (2009). Cannabinoids and the skeleton: from marijuana to reversal of bone loss. Annals of Medicine. 41(8), 560-7. Retrieved from

Baron, E.P. (2015, June). Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been… Headache, 55(6), 885-916. Retrieved from

Boychuck, D.G., Goddard, G., Mauro, G., and Orellana, M.F. (2015 Winter). The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review. Journal of Oral & Facial Pain and Headache, 29(1), 7-14. Retrieved from

Ephraim, P.L., Wegener, S.T., MacKenzie, E.J., Dillingham, T.R., and Pezzin, L.E. (2005, October). Phantom pain, residual limb pain, and back pain in amputees: results of a national survey. Archives of Physical Medicine and Rehabilitation, 86(10), 1910-9. Retrieved from

Jensen, B., Chen, J., Furnish, T., and Wallace, M. (2015, October). Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence. Current Pain and Headache Reports, 19(10), 524. Retrieved from

Lynch, M.E., and Campbell, F. (2011, November). Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. British Journal of Clinical Pharmacology, 72(5), 735-744. Retrieved from

Management of Residual Limb Pain. (n.d.) Amputee Coalition. Retrieved from

Tripp, D. A., Nickel, J. C., Katz, L., Krsmanovic, A., Ware, M. A., & Santor, D. (2014). A survey of cannabis (marijuana) use and self-reported benefit in men with chronic prostatitis/chronic pelvic pain syndrome. Canadian Urological Association Journal,8(11-12), E901–E905. Retrieved from

Wallace, M.S., Marcotte, T.D., Umlauf, A., Gouaux, B., and Atkinson, J.H. (2015, July). Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. Journal of Pain, 16(7), 616-27. Retrieved from

Weiss, L., Zeira, M., Reich, S., Har-Noy, M., Mechoulam, R., Slavin, S., and Gallily, R. (2006, March). Cannabidiol lowers incidence of diabetes in non-obese diabetic mice. Autoimmunity, 39(2), 143-51. Retrieved from

Weiss, L., Zeira, M., Reich, S., Slavin, S., Raz, I., Mechoulam, R., and Gallily, R. (2008, January). Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuropharmacology, 54(1), 244-9. Retrieved from

Whyte, L.S., Ford, L., Ridge, S.A., Cameron, G.A., Rogers, M.J. and Ross, R.A. (2012, April). Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro. British Journal of Pharmacology. 165(8), 2584-97. Retrieved from

Woodhams, S.G., Sagar, D.R., Burston, J.J., and Chapman, V. (2015). The role of the endocannabinoid system in pain. Handbook of Experimental Pharmacology, 227, 119-43. Retrieved from

Yazicioglu, K., Tagcu, I., Yilmaz, B., Goktepe, A.S., and Mohur, H. (2008, June). Osteoporosis: A factor on residual limb pain in traumatic trans-tibial amputations. Prosthetic and Orthotics International, 32(2), 172-8. Retrieved from

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