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Overview of Demyelinating Polyneuropathy

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a rare peripheral nerve disorder that causes weakness and sensory loss with a loss of reflexes. The disorder is caused by damage to the myelin sheath covering the nerves.

Scientists believe that CIDP is caused by a dysfunction in the immune system, which incorrectly perceives myelin as foreign and attacks it in an attempt to rid it of the body. Myelin enwraps nerve axon, serving as insulation so that electrical impulses are able to travel efficiently. Loss or damage of myelin slows electrical impulses or causes them to become lost.

Symptoms associated with CIDP include numbness, tingling, pain, loss of reflexes and weakness. Patients commonly experience foot drop and difficulties walking.

Treatment efforts for CIDP commonly include the administration of corticosteroids, which provide anti-inflammatory effects, intravenous immune globulins, which contain naturally-occurring antibodies, and plasma exchange, which helps to remove the harmful antibodies contained in the blood. If CIDP is left untreated, approximately 30% of patients will become wheelchair dependent. Early detection and treatment is effective at significantly limiting nerve damage caused by the disorder.

Findings: Effects of Cannabis on Demyelinating Polyneuropathy

Studies show the cannabis is an effective therapeutic option for treating neuropathic pain caused from disorders like CIDP and suggest that cannabinoid found in cannabis could potentially help limit the disorder’s progression.

Cannabis has demonstrated the ability to significantly lower pain levels in patients suffering from neuropathic and nociceptive pain, and has even to be effective against pain that has proven refractory to other treatments (Boychuck, Goddard, Mauro & Orellana, 2015) (Ware, et al., 2010). Even minimal doses of cannabis have been shown to significantly reduce neuropathic pain (Wilsey, et al., 2013). Long-term use of cannabis for pain therapy, studies show, is safe. After a year of regular use, patients with chronic pain were found to be at no greater risk of serious adverse effects than non-cannabis users (Ware, et al., 2015).

Cannabis has been shown to suppress the over activity of the body’s immune system, suggesting that it may also help in limit the progression of CIDP. The cannabinoids found in cannabis act upon both the CB1 and CB2 receptors of the endocannabinoid system, which works to regulate the immune system. Studies have shown that the administration of tetrahydrocannabinol (THC), one of the major cannabinoids found in cannabis, can suppress both inflammatory responses and the immune system to allow the body to recovery from immune-mediated injuries like CIDP (Nagarkatti, et al., 2009).



  1. All About CIDP. (n.d.). GBS/CIDP Foundational International. Retrieved from

  2. Boychuck, D.G., Goddard, G., Mauro, G., and Orellana, M.F. (2015 Winter). The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review. Journal of Oral & Facial Pain and Headache, 29(1), 7-14. Retrieved from

  3. De Filippis, D., D’Amico, A., and Iuvone, T. (2008, May). Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation. Journal of Neuroendocrinology, 20 Suppl 1, 20-5. Retrieved from

  4. Mechoulam, R., Sumariwalla, P.F., Feldmann, M., and Gallily, R. (2005). Cannabinoids in models of chronic inflammatory conditions. Phytochemistry Reviews, 4, 11-18. Retrieved from

  5. Nagarkatti, P., Pandey, R., Rieder, S.A., Hedge, V.L., and Nagarkatti, M. (2009, October). Cannabinoids as novel anti-inflammatory drugs. Future Medicinal Chemistry, 1(7), 1333-49. Retrieved from

  6. Ware, M.A., Wang, T., Shapiro, S., and Collet, J.P. (2015, September 15). Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS). The Journal of Pain. Retrieved from

  7. Ware, M.A., Wang, T., Shapiro, S., Robinson, A., Ducruet, T., Huynh, T., Gamsa, A., Bennett, G.J., and Collet, J.P. (2010, October 5). Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. Canadian Medical Association Journal, 182(14), E694-701. Retrieved from

  8. Wilsey, B., Marcotte, T., Deutsch, R., Gouaux, B., Sakai, S., and Donaghe, H. (2013, February). Low-dose vaporized cannabis significantly improves neuropathic pain. Journal of Pain, 14(2), 136-48. Retrieved from

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